Viral clade is associated with severity of symptomatic genotype 3 hepatitis E virus infections in Belgium, 2010-2018Article Published on 2023-01-012023-06-10 Journal: Journal of hepatology [Category] E형 간염, [키워드] clade CXCL10 hepatitis E virus pathogenicity risk factor Severity. [DOI] 10.1016/j.jhep.2022.08.033 PMC 바로가기
Measuring SARS-CoV-2 T cell immunity with a scalable qPCR-based assayArticle Published on 2022-11-012022-11-16 Journal: Nature biotechnology [Category] SARS, 치료기술, [키워드] cellular immunity CXCL10 detect Immunity mRNA PCR-based assay Quantitative SARS-CoV-2 T cell T cell response viral peptides Whole blood [DOI] 10.1038/s41587-022-01358-3 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics studyArticle Published on 2022-10-142022-11-15 Journal: eLife [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Abuse Accelerator Antibody Response association Biomarker BNT162b2 characterized clinical trial coronavirus Course COVID-19 COVID-19 patients Critical CXCL10 cytokine dataset develop Disease progression Donor drug early IFN signaling Eiger BioPharmaceuticals enrolled Enrollment heterogeneity Host identify immune immune marker immune response immune signature immunological immunology independent individual Infection Infectious disease Inflammation machine-learning majority marker MCP-3 MCP1 Medicine memory Mild mRNA vaccination natural infection outcome Outpatient outpatients Patient Pfizer-BioNTech plasma plasma protein Post-infection predict Predictive Predictive modeling proteomics provided receiving RIG-I SARS-CoV-2 SARS-CoV-2-infected patients severe symptoms Stanford Stanford University subsequent systems immunology T cell T cell memory the antibody response trajectory transcriptomics Vaccine viral shedding Virological viruses viruses. with COVID-19 [DOI] 10.7554/eLife.77943 PMC 바로가기
CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 CourseArticle Published on 2022-09-262022-11-15 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, 진단, [키워드] C4BPA C5aR1 CCL2 CCL3 CCR1 CFD chemokine chemokines CMV CMV status complement complement system. component Concentration contribute correlated Course courses COVID-19 COVID-19 patient CR1 CXCL10 CXCL8 Cytokine storm enrolled examined Factor groups healthy control Hyperinflammatory response ICU mechanisms molecular mRNA mRNA expression New non-ICU non-ICU patients pathogenesis and development pathophysiology plasma profile Prognostic factor protein level proteomic reduced Research SARS-CoV-2 Seropositivity severe COVID-19 significant difference time intervals [DOI] 10.3390/ijms231911338 PMC 바로가기
Immunogenicity profiling and distinct immune response in liver transplant recipients vaccinated with SARS-CoV-2 inactivated vaccinesArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-RBD antibody CD19 CD19+ CD3+ CD3+ CD19+ cell CD4+ cell CD4+ T cell Cell cells cellular immunity Clinical characteristics Concentration CXCL10 DNT effector memory enrolled groups humoral immune profiling immune response immune system immunogenicity immunotype inactivated Inactivated vaccine innate immune response liver liver transplant recipient Lymphocyte count monocyte NAb National Neutralizing Neutralizing antibodies neutralizing antibodies. neutralizing antibody plasma Population positive proportion provided recipient recipients reported responders responses SARS-CoV-2 SARS-CoV-2 inactivated vaccines severe adverse event single-cell T-cell three groups time TNF-alpha Type vaccination vaccination schedule were recorded [DOI] 10.3389/fimmu.2022.954177 PMC 바로가기
Plasma biomarkers for systemic inflammation in COVID-19 survivorsArticle Published on 2022-09-012022-11-15 Journal: Proteomics. Clinical applications [Category] SARS, 바이오마커, [키워드] Asymptomatic Biomarker Biomarkers coronavirus disease COVID-19 COVID-19 patient CXCL10 determine Diagnosis dysregulated evidenced exhibited healthy subject immunoassay Impact IMPROVE Infection Inflammation Inflammatory inflammatory protein long haulers. majority multiplex PASC plasma Post-infection Potential biomarker proportion Protein proteomics SARS-CoV-2 significant changes in significantly survivor Survivors Symptom systemic inflammation target Treatment upregulated while [DOI] 10.1002/prca.202200031 PMC 바로가기
Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patientsArticle Published on 2022-08-272022-10-05 Journal: Cell Death & Disease [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] acute phase addition analyzed anti-S Anti-spike antibody-dependent cellular cytotoxicity Apoptosis apoptotic build CD4 T cell CD4 T-cell Cell contribute Convalescent patients coronavirus 2 correlated COVID-19 COVID-19 patient CXCL10 death demonstrated disease severity early phase help humoral IgA IgG IgG response IgM Immunoglobulin individual infected individual infected individuals Infection inflammatory reaction lymphopenia magnitude marker membrane neutralization pathogenicity Patient plasma predominant programmed cell death Proteins reducing reported respiratory response responses SARS-CoV-2 nucleocapsid soluble Fas ligand specific IgG antibodies T-cell the S protein [DOI] 10.1038/s41419-022-05190-0 [Article Type] Article
Identification of key molecules in COVID-19 patients significantly correlated with clinical outcomes by analyzing transcriptomic dataArticle Published on 2022-08-222022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Admission Analysis analyzed Antiviral antiviral immune response antiviral immune responses caused clinical feature Clinical outcome clinical outcomes Cluster CMPK2 correlated correlation COVID-19 COVID-19 clusters COVID-19 patient COVID-19 patients CXCL10 D-dimer levels dataset datasets DEGs differentially expressed gene downregulation elevated EPSTI1 expressed expression expression profile Gene expression profiling Genes HERC6 human host cells ICU identification Ifi44 IFI44L IFI6 immune immune regulation intensive care intensive care unit Invasion involved leukocyte mechanical ventilatory support modulate nasopharyngeal OAS1 OAS2 OAS3 OASL outcome reducing RSAD2 SARS-CoV-2 SARS-COV-2 infection SERPING1 severity of COVID-19 significantly tissue transcriptomic data upregulated ventilatory viral loads Viral Loads. [DOI] 10.3389/fimmu.2022.930866 PMC 바로가기